생체재료연구단

Seung Ja Oh   Senior Researcher

Phone

02-958-5353

E-mail

seungja.oh@kist.re.kr

Office

L1-441

Homepage

– Ph.D., Department of Biochemistry and Molecular Biology

The Pennsylvania State University, USA (2011)

– B.S., Department of Biochemistry and Molecular Biology

The Pennsylvania State University, USA (2005)

– Korea Institute of Science and Technology, Seoul, Korea

Senior Research Scientist at Center for Biomaterials (Feb. 16~Present)

– Samsung Electronics Co., Ltd., Suwon, Korea

Research Staff at Samsung Advanced Institute of Technology (SAIT) (2012~2015)

– University of Pennsylvania, Philadelphia, USA

Postdoctoral Fellow at Perelman School of Medicine (2011~2012)

-3D Tissue Culture Platform for Drug Screening

-Cancer and Therapeutics

-Biomaterials and Immunoengineering

  • Lee J, Song B, Subbiah R, Chung J, Choi U, Park K, Kim S and OhSJ* “Effect of chain flexibility on cell adhesion: Semi-flexible model-based analysis of cell adhesion to hydrogels” ACS Macro Letters (Under review)
  • Lee H, Kim SM, Jang M, Kim S, Park K, OhSJ* “Nanoconstruct-induced apoptosis through downregulation of nucleolin-RTK pathway in cancer” Biomaterials (Under review)
  • Kim SM, Shin SC, Kim EK, Kim S, Park K, OhSJ* and Jang M “Simple in vivo gene editing via direct self-assembly of Cas9 Ribonucleoprotein Complexes for Cancer Treatment” ACS Nano (*Co-corresponding) (2018) Aug 28;12(8):7750-7760
  • Park B, Yang H, Ha, TH, Park HS, OhSJ, Ryu YS, Cho Y, Kim HS, Oh J, Lee DK, Kim C, Lee T, Seo M, Choi J, Jhon YM, Woo DH, Lee S, Kim SH, Lee HJ, Jun SC, Song HS, Park TH, Kim JH “Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities” Advanced Materials (2018) Jul;30(27)
  • Kang JM, Yoon JK, OhSJ and Kim SH “Synergistic Therapeutic Effect of Three-Dimensional Stem Cell Clusters and Angiopoietin-1 on Promoting Vascular Regeneration in Ischemic Region” Tissue Engineering Part A (2018) Apr;24(7-8):616-630
  • Kim SM, Yang Y, Hong Y, OhSJ and Jang M “ Cancer-derived nanovesicles as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting” (2017) J Control Release 28;266:8-16
  • Du P, Suhaeri M, Ha SS, OhSJ, S Kim and K Park “Human lung fibroblast-derived matrix facilitates vascular morphogenesis in 3D environment and enhances skin wound healing” (2017) Acta Biomater. Vol 54, 333-344
  • Suhaeri M, Subbiah R, Kim S, Kim C, OhSJ, S Kim and K Park “Novel Platform of Cardiomyocyte Culture and Coculture via Fibroblast-Derived Matrix-Coupled Aligned Electrospun Nanofiber” (2017) ACS Appl Mater Interfaces 9, 224−235
  • Park J, Kim I, Han S, Park I, Kim C, Bae J, OhSJ, Lee S, Kim JH, Woo D, He Y, Augustin HG, Kim I, Lee D and Koh GY “Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor ” (2016) Cancer Cell Volume 30, Issue 6,p953–967, 12
  • Lee JM, Lee SH, Hwang JW, OhSJ, Kim B, Jung S, Shim SH, Lin PW, Lee SB, Cho MY, Koh YJ, Kim SY, Ahn S, Lee J, Kim KM, Cheong KH, Choi J, Kim KA, “ Novel strategy for a bispecific antibody: induction of dual target internalization and degradation” (2016) Oncogene 2016 Feb 8
  • Han S, Lee SJ, Kim KE, Lee HS, Oh N, Park I, Ko E, OhSJ, Lee YS, Kim D, Lee S, Lee DH, Lee KH, Chae SY, Lee JH, Kim SJ, Kim HC, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin HG, Song PH, Kim YI, Kim P, Kim I, Koh GY “Amelioration of Sepsis by Tie2 Activation-Induced Vascular Protection” (2016) Sci Transl Med. 2016 Apr 20;8(335):335ra55
  • Monteleon CL, McNeal A, Duperret EK, OhSJ, Schapira E, Ridky TW, “IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression” (2015) J Invest Dermatol. 2015 Sep;135(9):2258-65
  • Lee HS*, OhSJ*, Lee KH, Lee YS, Ko E, Kim KE, Kim HC, Kim S, Song PH, Kim YI, Kim C, Han S., “Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with α5β1 integrin” (2014) J Biol Chem. 2014 Nov 7;289(45):31330-40. (*Equal contribution)
  • Oh YM, Lee SB, Choi J, Suh HY, Shim S, Song YJ, Kim B, Lee JM, OhSJ, Jeong Y, Cheong KH, Song PH, Kim KA, “USP8 modulates ubiquitination of LRIG1 for Met degradation” (2014) Sci Rep. 2014 May 15;4:4980.
  • Duperret EK, OhSJ*, McNeal A, Prouty SM, Ridky TW, “Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors” (2014) Cell Cycle. 2014;13 (10):1551-9.
  • Seung Ja Oh and Loraine C. Santy, “Phosphoinositide Specificity Determines Which Cytohesins Regulates β1 Integrin Recycling” (2012) JCS 2012 Jul 1;125(Pt 13):3195-201
  • Seung Ja Oh and Loraine C. Santy, “Differential Effects of cytohesin 2 and 3 on β1 Integrin Recycling ” (2010) JBC 285 (19) 14610-14616
  • Jae Kun Shim, Sun Wook Kim, SeungJaOh, Ning Kang, Vladimir M. zatsiorsky and Mark L. Latash, “Plastic changes in interhemispheric inhibition with practice of a two-hand force production task: a transcranial magnetic stimulation study” (2005) Neurosci Lett 10;374(2) 104-8

Patent

  • Kyung Eun Kim, SeungJaOh, Hyo Seon LEE, Sang Yeul Han “Anti-ang2 antibody” US9828422B2/ EP2832746B1
  • Hyo Seon LEE, Kyung Eun Kim, SeungJaOh, Sang Yeul Han “Method of blocking vascular leakage using an anti-ang2 antibody” US9902767B2 / EP2835380B1
  • Ji Min LEE, Bo Gyou KIM, SeungJaOH, Kyung Ah KIM “Biomarker PNCK for predicting effect of a dual-targeting agent” US 20160033518 A1
  • Ji Min LEE, Bo Gyou KIM, SeungJaOH, Kyung Ah KIM, Saet Byoul LEE, Jae Woong HWANG “Biomarker HSP90 for predicting effect of a c-Met inhibitor” US9956244B2
  • Seung Ja Oh, Kyung Ah Kim, Bo Gyou Kim, Seung Hyun Lee, Ji Min Lee “Anti-c-Met/Anti-Ang2 Bispecific Antibody” US9808507B2
  • Seung Hyun Lee, Soo Yeon Jung, Bo Gyou Kim, SeungJaOh, Ji Min Lee “Polypeptide, AntiVEGF Antibody, and Anti-c-Met/Anti-VEGF Bispecific Antibodies comprising the same” US 20160090427 A1