윤홍열 선임연구원

전화번호

02-958-5948

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seerou@kist.re.kr

위치

L1-122

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Ph.D. in School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Korea  2015. 8

Thesis Title : Hyaluronic Acid-Based Nanomedicines for Tumor Targeted Therapy

Advisor: Prof. Jae Hyung Park

B.S. in Department of Advanced Polymer and Fiber Materials, Kyung Hee University, Korea 2010. 2

Senior research Scientist  2018.08 – present

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Korea

Post-doctoral researcher  2015 – 2018.07

(Advisor: Dr. Ick Chan Kwon and Dr. Kwangmeyung Kim)

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Korea

Research Trainee  2010 – 2015

(Advisor: Dr. Ick Chan Kwon and Dr. Kwangmeyung Kim)

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Korea.

  • Nanomedicines for cancer immunotherapy
  • Metabolic glycoengineering and bioorthogonal click chemistry based in vivo theranostic applications (targeted imaging and therapy using nanocarriers)
  • Multimodal imaging using nano-bio materials
  1. Shim, M. K.*, Yoon, H. Y.*, Lee, S., Jo, M. K., Park, J., Kim, J. H., … & Kim, K. (2017). Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis. Scientific Reports, 7, 16635.
  2. Han, S. S.* Yoon, H. Y.* Yhee, J. Y., Cho, M. O., Shim, H. E., Jeong, J. E., … & Huh, K. M. (2017). In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering. Polymer Chemistry.
  3. Yoon, H. Y.*, Koo, H., Kim, K., & Kwon, I. C. (2017). Molecular imaging based on metabolic glycoengineering and bioorthogonal click chemistry. Biomaterials. 132, 28-36.
  4. Yoon, H. Y.*, Shin, M. L., Shim, M. K., Lee, S., Na, J. H., Koo, H., … & Kwon, I. C. (2017). Artificial Chemical Reporter Targeting Strategy Using Bioorthogonal Click Reaction for Improving Active-Targeting Efficiency of Tumor. Molecular Pharmaceutics, 14(5), 1558-1570.
  5. Yoon, H. Y.* Jeon, S., You, D. G., Park, J. H., Kwon, I. C., Koo, H., & Kim, K. (2016). Inorganic Nanoparticles for Image-Guided Therapy. Bioconjugate chemistry, 28(1), 124-134.
  6. M.K. Shim*, H.Y. Yoon*, J.H. Ryu, H. Koo, S. Lee, J.H. Park, J.H. Kim, S. Lee, M.G. Pomper, I.C. Kwon, Cathepsin B‐Specific Metabolic Precursor for In Vivo Tumor‐Specific Fluorescence Imaging, Angewandte Chemie 128(47) (2016) 14918-14923. (IF = 11.709)
  7. N.V. Rao*, H.Y. Yoon*, H.S. Han, H. Ko, S. Son, M. Lee, H. Lee, D.G. Jo, Y.M. Kang, J.H. Park, Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment, Expert opinion on drug delivery, 13 (2016) 239-252. (IF=4.84)
  8. Y.H. Lee*, H.Y. Yoon*, J.M. Shin, G. Saravanakumar, K.H. Noh, K.H. Song, J.H. Jeon, D.W. Kim, K.M. Lee, K. Kim, I.C. Kwon, J.H. Park, T.W. Kim, A polymeric conjugate foreignizing tumor cells for targeted immunotherapy in vivo, Journal of controlled release : official journal of the Controlled Release Society, 199 (2015) 98-105. (IF=7.71)
  9. H.Y. Yoon*, S. Son*, S.J. Lee, D.G. You, J.Y. Yhee, J.H. Park, M. Swierczewska, S. Lee, I.C. Kwon, S.H. Kim, K. Kim, M.G. Pomper, Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: sequential delivery of doxorubicin and Bcl-2 siRNA, Scientific reports, 4 (2014) 6878. (IF=5.58)
  10. H.Y. Yoon*, H. Koo*, K.Y. Choi, I. Chan Kwon, K. Choi, J.H. Park, K. Kim, Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery, Biomaterials, 34 (2013) 5273-5280. (IF=8.56)
  11. H.Y. Yoon*, H.R. Kim*, G. Saravanakumar, R. Heo, S.Y. Chae, W. Um, K. Kim, I.C. Kwon, J.Y. Lee, D.S. Lee, J.C. Park, J.H. Park, Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting, Journal of controlled release : official journal of the Controlled Release Society, 172 (2013) 653-661. (IF=7.71)
  12. H.Y. Yoon*, G. Saravanakumar*, R. Heo, S.H. Choi, I.C. Song, M.H. Han, K. Kim, J.H. Park, K. Choi, I.C. Kwon, K. Park, Hydrotropic magnetic micelles for combined magnetic resonance imaging and cancer therapy, Journal of controlled release : official journal of the Controlled Release Society, 160 (2012) 692-698. (IF=7.71)
  13. H.Y. Yoon*, H. Koo*, K.Y. Choi, S.J. Lee, K. Kim, I.C. Kwon, J.F. Leary, K. Park, S.H. Yuk, J.H. Park, K. Choi, Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy, Biomaterials, 33 (2012) 3980-3989. (IF=8.56)
  14. You, D. G., Yoon, H. Y., Jeon, S., Um, W., Son, S., Park, J. H., … & Kim, K. (2017). Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound. Nano convergence, 4(1), 30.
  15. Lee, S., Han, H., Koo, H., Na, J. H., Yoon, H. Y., Lee, K. E., … & Kim, K. (2017). Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound. Journal of Controlled Release.
  16. Yhee, J. Y., Jeon, S., Yoon, H. Y., Shim, M. K., Ko, H., Min, J., … & Suh, M. (2017). Effects of tumor microenvironments on targeted delivery of glycol chitosan nanoparticles. Journal of Controlled Release.
  17. Lee, S., Jung, S., Koo, H., Na, J. H., Yoon, H. Y., Shim, M. K., … & Kwon, I. C. (2017). Nano-sized metabolic precursors for heterogeneous tumor-targeting strategy using bioorthogonal click chemistry in vivo. Biomaterials.
  18. Kwon, S. P., Jeon, S., Lee, S. H., Yoon, H. Y., Ryu, J. H., Choi, D., … & Kwon, I. C. (2017). Thrombin-activatable fluorescent peptide incorporated gold nanoparticles for dual optical/computed tomography thrombus imaging. Biomaterials.
  19. Lee, S., Han, H., Koo, H., Na, J. H., Yoon, H. Y., Lee, K. E., … & Kim, K. (2017). Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound. Journal of Controlled Release.
  20. Lee, A., De Mei, C., Fereira, M., Marotta, R., Yoon, H. Y., Kim, K., … & Decuzzi, P. (2017). Dexamethasone-loaded polymeric nanoconstructs for monitoring and treating inflammatory bowel disease. Theranostics, 7(15), 3653.
  21. Yhee, J. Y., Yoon, H. Y., Kim, H., Jeon, S., Hergert, P., Im, J., … & Nho, R. S. (2017). The effects of collagen-rich extracellular matrix on the intracellular delivery of glycol chitosan nanoparticles in human lung fibroblasts. International journal of nanomedicine, 12, 6089.
  22. Jung, B., Shim, M. K., Park, M. J., Jang, E. H., Yoon, H. Y., Kim, K., & Kim, J. H. (2017). Hydrophobically modified polysaccharide-based on polysialic acid nanoparticles as carriers for anticancer drugs. International journal of pharmaceutics, 520(1), 111-118.
  23. Son, S., Kim, N., You, D. G., Yoon, H. Y., Yhee, J. Y., Kim, K., … & Kim, S. H. (2017). Antitumor therapeutic application of self-assembled RNAi-AuNP nanoconstructs: Combination of VEGF-RNAi and photothermal ablation. Theranostics, 7(1), 9.
  24. J.Y. Yhee, Y.J. Kim, J.H. Ryu, H.Y. Yoon, H. Chang, J.H. Park, H. Lee, H.S. Jang, U. Jeong, K. Kim, S.W. Kang, Cathepsin B Imaging to Predict Quality of Engineered Cartilage, Macromolecular bioscience, 15 (2015) 1224-1232. (IF=3.85)
  25. S.J. Lee, S. Yook, J.Y. Yhee, H.Y. Yoon, M.G. Kim, S.H. Ku, S.H. Kim, J.H. Park, J.H. Jeong, I.C. Kwon, S. Lee, H. Lee, K. Kim, Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo, Journal of controlled release : official journal of the Controlled Release Society, 220 (2015) 631-641. (IF=7.71)
  26. G.Y. Lee, J.H. Kim, K.Y. Choi, H.Y. Yoon, K. Kim, I.C. Kwon, K. Choi, B.H. Lee, J.H. Park, I.S. Kim, Hyaluronic acid nanoparticles for active targeting atherosclerosis, Biomaterials, 53 (2015) 341-348. (IF=8.56)
  27. R.Heo, H.Y. Yoon, H. Ko, J.M. Shin, J. Jeon, Y.S. Chae, Y.M. Kang, D. Kim, D.S. Lee, J.H. Park, Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo, Chemical communications (Cambridge, England), 51 (2015) 16656-16659. (IF=6.83)
  28. S. Jeon, H. Ko, N. Vijayakameswara Rao, H.Y. Yoon, D.G. You, H.S. Han, W. Um, G. Saravanakumar, J.H. Park, A versatile gold cross-linked nanoparticle based on triblock copolymer as the carrier of doxorubicin, RSC Advances, 5 (2015) 70352-70360. (IF=3.84)
  29. T. Thambi, V.G. Deepagan, H.Y. Yoon, H.S. Han, S.H. Kim, S. Son, D.G. Jo, C.H. Ahn, Y.D. Suh, K. Kim, I.C. Kwon, D.S. Lee, J.H. Park, Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery, Biomaterials, 35 (2014) 1735-1743. (IF=8.56)
  30. J.H. Park, H.J. Cho, H.Y. Yoon, I.S. Yoon, S.H. Ko, J.S. Shim, J.H. Cho, J.H. Park, K. Kim, I.C. Kwon, D.D. Kim, Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery, Journal of controlled release : official journal of the Controlled Release Society, 174 (2014) 98-108. (IF=7.71)
  31. S. H. Kim, J.H. Kim, D.G. You, G. Saravanakumar, H.Y. Yoon, K.Y. Choi, T. Thambi, V.G. Deepagan, D.G. Jo, J.H. Park, Self-assembled dextran sulphate nanoparticles for targeting rheumatoid arthritis, Chemical communications (Cambridge, England), 49 (2013) 10349-10351. (IF=6.83)
  32. H.S. Min, S. Son, T.W. Lee, H. Koo, H.Y. Yoon, J.H. Na, Y. Choi, J.H. Park, J. Lee, M.H. Han, R.-W. Park, I.-S. Kim, S.Y. Jeong, K. Rhee, S.H. Kim, I.C. Kwon, K. Kim, Liver-Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination, Advanced Functional Materials, 23 (2013) 5518-5529. (IF=11.81)
  33. H. S. Han, J. Lee, H.R. Kim, S.Y. Chae, M. Kim, G. Saravanakumar, H.Y. Yoon, D.G. You, H. Ko, K. Kim, I.C. Kwon, J.C. Park, J.H. Park, Robust PEGylated hyaluronic acid nanoparticles as the carrier of doxorubicin: mineralization and its effect on tumor targetability in vivo, Journal of controlled release : official journal of the Controlled Release Society, 168 (2013) 105-114. (IF=7.71)
  34. D-E. Lee, A.Y. Kim, H.Y. Yoon, K.Y. Choi, I.C. Kwon, S.Y. Jeong, J.H. Park, K. Kim, Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging, Journal of Materials Chemistry, 22 (2012) 10444-10447. (IF=6.626)
  35. M. Swierczewska, K.Y. Choi, E.L. Mertz, X. Huang, F. Zhang, L. Zhu, H.Y. Yoon, J.H. Park, A. Bhirde, S. Lee, X. Chen, A facie, one-step nanocarbon functionalization for biomedical applications, Nano letters, 12 (2012) 3613-3620. (IF=13.59)
  36. K.Y. Choi, E.J. Jeon, H.Y. Yoon, B.S. Lee, J.H. Na, K.H. Min, S.Y. Kim, S.J. Myung, S. Lee, X. Chen, I.C. Kwon, K. Choi, S.Y. Jeong, K. Kim, J.H. Park, Theranostic nanoparticles based on PEGylated hyaluronic acid for the diagnosis, therapy and monitoring of colon cancer, Biomaterials, 33 (2012) 6186-6193. (IF=8.56)
  37. H.J. Cho, I.S. Yoon, H.Y. Yoon, H. Koo, Y.J. Jin, S.H. Ko, J.S. Shim, K. Kim, I.C. Kwon, D.D. Kim, Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin, Biomaterials, 33 (2012) 1190-1200. (IF=8.56)
  38. H.J. Cho, H.Y. Yoon, H. Koo, S.H. Ko, J.S. Shim, J.H. Cho, J.H. Park, K. Kim, I.C. Kwon, D.D. Kim, Hyaluronic acid-ceramide-based optical/MR dual imaging nanoprobe for cancer diagnosis, Journal of controlled release : official journal of the Controlled Release Society, 162 (2012) 111-118. (IF=7.71)
  39. T. Thambi, H.Y. Yoon, K. Kim, I.C. Kwon, C.K. Yoo, J.H. Park, Bioreducible block copolymers based on poly(ethylene glycol) and poly(gamma-benzyl L-glutamate) for intracellular delivery of camptothecin, Bioconjugate chemistry, 22 (2011) 1924-1931. (IF=4.51)
  40. K. Y. Choi, H.Y. Yoon, J.H. Kim, S.M. Bae, R.W. Park, Y.M. Kang, I.S. Kim, I.C. Kwon, K. Choi, S.Y. Jeong, K. Kim, J.H. Park, Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy, ACS nano, 5 (2011) 8591-8599. (IF=12.88)
  41. K. Y. Choi, K.H. Min, H.Y. Yoon, K. Kim, J.H. Park, I.C. Kwon, K. Choi, S.Y. Jeong, PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo, Biomaterials, 32 (2011) 1880-1889. (IF=8.56)
  42. H. J. Cho, H.Y. Yoon, H. Koo, S.H. Ko, J.S. Shim, J.H. Lee, K. Kim, I.C. Kwon, D.D. Kim, Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic(R) for tumor-targeted delivery of docetaxel, Biomaterials, 32 (2011) 7181-7190. (IF=8.56)
  43. G.Saravanakumar, K.Y. Choi, H.Y. Yoon, K. Kim, J.H. Park, I.C. Kwon, K. Park, Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel, International journal of pharmaceutics, 394 (2010) 154-161. (IF=3.65)
  44. K. Y. Choi, H. Chung, K.H. Min, H.Y. Yoon, K. Kim, J.H. Park, I.C. Kwon, S.Y. Jeong, Self-assembled hyaluronic acid nanoparticles for active tumor targeting, Biomaterials, 31 (2010) 106-114. (IF=8.56)