테라그노시스연구단

Yoosoo Yang    Senior Researcher

Phone

02-958-6655

E-mail

ysyang@kist.re.kr

Office

L1-128

Homepage

Ph.D. Sungkyunkwan University, Biotechnology and Bioengineering (2012)

M.S. Sungkyunkwan University, Biotechnology and Bioengineering (2009)

B.S. Sungkyunkwan University, Genetic Engineering (2007)

 

Senior Research Scientist, Center for Theragnosis, Korea Institute of Science and Technology (KIST) (2014~)

Associate Professor, Division of Bio-Medical Science & Technology, UST KIST School (2017~)

Assistant Professor, Biological Chemistry Program, University of Science and Technology (UST) (2015~2017)

Visiting Scholar, Dept. of Biochemistry, Biophysics and Molecular Biology, Iowa State University (2013)

Postdoctoral Fellow, Single-molecule imaging Lab, KIST (2012~2014)

– Elucidation of exosome-mediated intermembrane signaling

– Development of exosome-based platform for therapeutic applications (e.g., cancer immunotherapy), using membrane engineering

– Understanding of membrane biology underlying membrane fusion pathways for the treatment of human disease

ㅇ PUBLICATION

Yang Y1, Kong B, Jung Y, PARK JB, Oh JM, Hwang J, Cho J Y, Kweon DH. Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor-Derived Peptides for Regulation of Mast Cell Degranulation. Front Immunol (2018)

Yang Y1,*, Hong Y, Cho E, Kim G B, Kim IS. Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery. J Extracell Vesicles (2018)

Cho E, Nam GH, Hong Y, Kim YK, Kim DH, Yang Y*, Kim IS. Comparison of exosomes and ferritin protein nanocages for the delivery of membrane protein therapeutics. J Control Release. (2018)

Hong Y, Nam GH, Koh E, Jeon S, Kim GB, Jeong C, Kim DH, Yang Y*, Kim IS. Exosome as a vehicle for delivery of membrane protein therapeutics, PH20 for enhanced tumor penetration and anti-tumor efficacy. Adv Funct Mat. (2018)

Jo SD, Nam GH, Kwak G, Yang Y*, Kwon IC. Harnessing designed nanoparticles: Current strategies and future perspectives in cancer immunotherapy.  Nanotoday. (2017)

Yang Y1,*, Hong Y, Nam GH, Chung JH, Koh E, Kim IS. Virus-mimetic fusogenic exosomes for direct delivery of integral membrane proteins to target cell membranes. Adv Mat. (2017)

Koh E, Lee EJ, Nam GH, Hong Y , Cho E, Yang Y*, Kim IS. Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis. Biomaterials. (2017)

Heo P, Yang Y1, Han KY, Kong B, Shin JH, Jung Y, Jeong C, Shin J, Shin YK, Ha TJ, Kweon DH. A chemical controller of SNARE-driven membrane fusion that primes vesicles for Ca2+-triggered millisecond exocytosis. J Am Chem Soc. (2016)

Yang Y1, Kim J, Kim YS, Kim HY, Shin YK. Amyloid-β may impair SNARE-mediated exocytosis by direct binding to syntaxin 1a. Cell Reports (2015)