양유수 선임연구원

전화번호

02-958-6655

이메일

ysyang@kist.re.kr

위치

L1-128

홈페이지

2012  성균관대학교, 생명공학, 박사

2009  성균관대학교, 생명공학, 석사

2007  성균관대학교, 생명공학, 학사

2014- 한국과학기술연구원, 테라그노시스연구센터 선임연구원

2015- UST KIST스쿨, Bio-Med 융합전공, 부교수

2015- UST KIST스쿨, Bio-Med 융합전공, 부교수

2013 Iowa State University, 방문연구원

2012-2014 한국과학기술연구원, 박사후연구원

엑소좀 및 막생물학 연구를 통한 세포간 의사소통 이해

– membrane engineering을 이용한 엑소좀 기반 치료 기술 개발 (, 항암 면역 치료)

ㅇ 대표 논문

Yang Y1, Kong B, Jung Y, PARK JB, Oh JM, Hwang J, Cho J Y, Kweon DH. Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor-Derived Peptides for Regulation of Mast Cell Degranulation. Front Immunol (2018)

Yang Y1,*, Hong Y, Cho E, Kim G B, Kim IS. Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery. J Extracell Vesicles (2018)

Cho E, Nam GH, Hong Y, Kim YK, Kim DH, Yang Y*, Kim IS. Comparison of exosomes and ferritin protein nanocages for the delivery of membrane protein therapeutics. J Control Release. (2018)

Hong Y, Nam GH, Koh E, Jeon S, Kim GB, Jeong C, Kim DH, Yang Y*, Kim IS. Exosome as a vehicle for delivery of membrane protein therapeutics, PH20 for enhanced tumor penetration and anti-tumor efficacy. Adv Funct Mat. (2018)

Jo SD, Nam GH, Kwak G, Yang Y*, Kwon IC. Harnessing designed nanoparticles: Current strategies and future perspectives in cancer immunotherapy.  Nanotoday. (2017)

Yang Y1,*, Hong Y, Nam GH, Chung JH, Koh E, Kim IS. Virus-mimetic fusogenic exosomes for direct delivery of integral membrane proteins to target cell membranes. Adv Mat. (2017)

Koh E, Lee EJ, Nam GH, Hong Y , Cho E, Yang Y*, Kim IS. Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis. Biomaterials. (2017)

Heo P, Yang Y1, Han KY, Kong B, Shin JH, Jung Y, Jeong C, Shin J, Shin YK, Ha TJ, Kweon DH. A chemical controller of SNARE-driven membrane fusion that primes vesicles for Ca2+-triggered millisecond exocytosis. J Am Chem Soc. (2016)

Yang Y1, Kim J, Kim YS, Kim HY, Shin YK. Amyloid-β may impair SNARE-mediated exocytosis by direct binding to syntaxin 1a. Cell Reports (2015)

 

ㅇ 논문

  • 1. Gi Beom Kim, Gi-Hoon Nam, Yeonsun Hong, Jiwan Woo, Yakdol Cho, Ick Chan Kwon, Yoosoo Yang*, In-San Kim (2020) “Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity” Sci Adv 6(27) eaaz2083
  • 2. Gi‐Hoon Nam, Ki Joo Pahk, Sangmin Jeon, Hyun‐Ju Park, Gi Beom Kim, Seung Ja Oh, Kwangmeyung Kim, Hyungmin Kim, Yoosoo Yang* (2020) “Investigation of the Potential Immunological Effects of Boiling Histotripsy for Cancer Treatment” Adv Therap, 1900214
  • 3. Yeonsun Hong, Yoon Kyoung Kim, Gi Beom Kim, Gi-Hoon Nam, Seong A Kim, Yoon Park, Yoosoo Yang*, In-San Kim* (2019) “Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity” J Extracell Vesicles 28;8(1):1670893
  • 4. Yoosoo Yang1,*, Gi-Hoon Nam, Gi Beom Kim, Yoon Kyoung Kim, In-San Kim* (2019) “Intrinsic cancer vaccination” Adv Drug Deliv Rev 151-152:2-22
  • 5. Yoosoo Yang1, Byoungjae Kong1, Younghoon Jung, Joon-Bum Park, Jung-Mi Oh, Jaesung Hwang, Jae-Yeol Cho, Dae-Hyuk Kweon* (2018) “SNARE-derived peptides for regulation of mast cell degranulation” Front Immunol, 725(9)
  • 6. Yoosoo Yang1,*, Yeonsun Hong, Eunji Cho, Gi Beom Kim, and In-San Kim* (2018) “Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery” J Extracell Vesicles, 7(1);144031
  • 7. Yeonsun Hong, Gi-Hoon Nam, Eunee Koh, Sangmin Jeon, Gi Beom Kim, Cherlhyun Jeong, Dong-Hwee Kim, Yoosoo Yang*, In-San Kim* (2018) “Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy” Adv Func Mat, 28(5):170307
  • 8. Sung Duk Jo, Gi-Hoon Nam, Gijung Kwak, Yoosoo Yang*, Ick Chan Kwon*, (2017) “Harnessing designed nanoparticles: Current strategies and future perspectives in cancer immunotherapy” Nano Today, 17(2017):23-37
  • 9. Yoosoo Yang1,*, Yeonsun Hong, Gi-Hoon Nam, Jin Hwa Chung, Eunee Koh, and In-San Kim# (2017) “Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes” Adv Mater, 29(13)
  • 10. Eunee Koh, Eun Jung Lee, Gi-Hoon Nam, Yeonsun Hong, Eunji Cho, Yoosoo Yang*, and In-San Kim* (2017) “Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis” Biomaterials, 121:121-129

 

ㅇ 대표 특허 정보

  1. 신규 항암 조성물 (출원) 대한민국; 10-2017-0126259; 2017.09.28
  2. 항암치료용 신규 재조합 엑소좀 (출원) 대한민국; 10-2017-0126202; 2018.09.28.
  3. Rho-연관된 단백질 키나제 저해제를 포함하는 면역 반응 증강용 조성물 및 이를 이용한 방법 (등록) 대한민국; 10-1892154; 2018.08.21 / (출원) USA; 62662340; 2018.04.25
  4. 하이알유로니데이즈 포함 신규 재조합 엑소좀 및 그의 용도 (출원), 대한민국; 10-2017-0039407; 2017.03.28 / USA; 15996729; 2018.06.04 / Japan; 2018-106832; 2018.06.04
  5. 신규 엑소좀 계열 항암제 (출원) Korea; 10-2017-0184227 / PCT; PCT-KR2017-015784; 2017.12.29
  6. 신규 재조합 엑소좀 및 그의 용도 (출원) 대한민국; 10-2017-0089840 / USA;15650272/ Japan; 2017-151429; 2017.07.14
  7. 신규 나노케이지 및 그의 용도 (출원) 대한민국; 10-2017-00900608 / PCT; PCT-KR-2017-007679; 2017.07.17

 

ㅇ 기술이전

– 신규 재조합 엑소좀 및 그의 용도 (2018-04-06)- 주식회사 탠덤