이철주 책임연구원

전화번호

02-958-6788

이메일

clee270@kist.re.kr

위치

L7-235

1992.3-1997.8 서울대학교 미생물학과 박사 (전공: 생물물리학)

1990.3-1992.2 서울대학교 미생물학과 석사

1986.3-1990.2 서울대학교 미생물학과 학사

  • 1997.9-1999.11 생명공학연구원 단백질긴장상태연구센터, 포스트닥터
  • 2000.1-2001.11 Northwestern University, Illinois, USA (Postdoctoral fellow)
  • 2001.12-2002.11 생명공학연구원, 객원선임연구원
  • 2002.12-2010.2 한국과학기술연구원 생체과학연구부, 선임연구원
  • 2003.09-2003.12 Osaka Univ. Japan (Visiting Professor)
  • 2005.3-2011.2 한국과학기술연합대학원대학교 (University of Science and Technology) 이학부, 부교수 (생체분자과학과)
  • 2010.3-현재 한국과학기술연구원 의공학연구소 테라그노시스연구센터, 책임연구원
  • 2011.3-2017.3 한국과학기술연합대학원대학교 (University of Science and Technology) 이학부, 교수 (생물화학과, 시스템생물학전공)
  • 2014.4-2017.3 한국과학기술연구원 의공학연구소 테라그노시스연구센터, 연구센터장
  • 2016.2-현재 경희대학교 융합과학기술학과 (KHU-KIST), 학연교수
  • 2017.4-현재 한국과학기술연합대학원대학교 (University of Science and Technology), KIST school, Division of Bio-Medical Science & Technology, 겸임교수
  • 2019.6–2019.8 The Scripps Research Institute at La Jolla, California, Visiting Investigator

– 프로테오믹스 요소기술개발

– 질병 바이오마커 발굴

– 단백질 Post-translational Modification 분석법 개발

– 줄기세포유래 분비단백체 분리 및 분석 플랫폼 구축

Kwon Y, Ju S, Kaushal P, Lee JW, Lee C. Neutralizing the Detrimental Effect of

an N-Hydroxysuccinimide Quenching Reagent on Phosphopeptide in Quantitative

Proteomics. Anal Chem. 2018;90(5):3019-3023

 

Yeom J, Ju S, Choi Y, Paek E, Lee C. Comprehensive analysis of human protein

N-termini enables assessment of various protein forms. Sci Rep. 2017;7(1):6599

 

Seo J, Lee EW, Sung H, Seong D, Dondelinger Y, Shin J, Jeong M, Lee HK, Kim

JH, Han SY, Lee C, Seong JK, Vandenabeele P, Song J. CHIP controls necroptosis

through ubiquitylation- and lysosome-dependent degradation of RIPK3. Nat Cell

Biol. 2016;18(3):291-302.

Yeom J, Kabir MH, Lim B, Ahn HS, Kim SY, Lee C. A proteogenomic approach for

protein-level evidence of genomic variants in cancer cells. Sci Rep. 2016;6:35305

Shin J, Kim HJ, Kim G, Song M, Woo SJ, Lee ST, Kim H, Lee C. Discovery of

melanotransferrin as a serological marker of colorectal cancer by secretome

analysis and quantitative proteomics. J Proteome Res. 2014;13(11):4919-31.

 

논문

  • Oh S, Yeom J, Cho HJ, Kim JH, Yoon SJ, Kim H, Sa JK, Ju S, Lee H, Oh MJ, Lee W, Kwon Y, Li H, Choi S, Han JH, Chang JH, Choi E, Kim J, Her NG, Kim SH, Kang SG, Paek E, Nam DH, Lee C, Kim HS. Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities. Nat Commun. 2020 Jul 3;11(1):3288.
  • Ju S, Kwon Y, Kim JM, Park D, Lee S, Lee JW, Hwang CS, Lee C. iNrich, Rapid and Robust Method to Enrich N-Terminal Proteome in a Highly Multiplexed Platform. Anal Chem. 2020 May 5;92(9):6462-6469.
  • Shin J, Rhim J, Kwon Y, Choi SY, Shin S, Ha CW, Lee C. Comparative analysis of differentially secreted proteins in serum-free and serum-containing media by using BONCAT and pulsed SILAC. Sci Rep. 2019 Feb 28;9(1):3096.
  • Kim JM, Seok OH, Ju S, Heo JE, Yeom J, Kim DS, Yoo JY, Varshavsky A, Lee C, Hwang CS. Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science. 2018 Nov 30;362(6418):eaat0174.
  • Kwon Y, Ju S, Kaushal P, Lee JW, Lee C. Neutralizing the Detrimental Effect of an N-Hydroxysuccinimide Quenching Reagent on Phosphopeptide in Quantitative Proteomics. Anal Chem. 2018 Mar 6;90(5):3019-3023
  • [6] GB Kim, GH Nam, Y Hong, J Woo, Y Cho, IC Kwon, Y Yang, IS Kim Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity. Science Advances 6 (27), eaaz2083, 2020