한서정 선임연구원

Phone

+82-2-958-5135

E-mail

sjhan@kist.re.kr

Office

L3, L3663

  • 2011.09.-2016.06. 박사, California Institute of Technology (Caltech), 유기화학전공
  • 2008.02.-2010.02. 석사, 서강대학교, 유기화학전공
  • 2004.02.-2008.02. 학사 (summa cum laude), 서강대학교 화학전공
  • 2019.03.-현재 KIST UST 부교수
  • 2018.03.-현재 한국과학기술연구원 (KIST) 선임연구원
  • 2017.09.-2018.02. 한국과학기술연구원 (KIST) 연구원
  • 2016.09.-2017.08. University of California, Berkeley 박사 후 연수
  • 2010.08.-2011.06. 한국화학연구원 연구원

신약탐색, 의약화학, 유기화학반응개발, 천연물전합성

– 논문

  • 17. “Identification of Highly Selective Type II Kinase Inhibitors with Chiral Peptidomimetic Tails,” Seo-Jung Han*, Jae Eun Jung, Do Hee Oh, Minsup Kim, In Ho Park, Eunkyeong Jeon, Jeon-Soo Shin, Dongkeun Hwang, Hee Jin Jeong, Art E. Cho, Duck-Hyung Lee, Taebo Sim*, Under revision. (* Co-corresponding authors)
  • 16. “A Synthetic Strategy toward Eight-Membered Cyclic Amines by Cycloetherification and Claisen Rearrangement,” Seo-Jung Han†, Marchello A. Cavitt†, Brian M. Stoltz, Org. Lett. 2021, 23, 3300–3303. (†Contributed equally)
  • 15. “Enantioselective Allenoate-Claisen Rearrangement using Chiral Phosphate Catalysts”, Javier Miró†, Tobias Gensch†, Mario Ellwart, Seo-Jung Han, Hsin-Hui Lin, Matthew S. Sigman, F. Dean Toste, J. Am. Chem. Soc. 2020, 142, 6390–6399. (†Contributed equally)
  • 14. “Identification of a novel turn-onalbumin binding small-molecule bioprobe in live zebrafish and its potential application in drug discovery,” Hang-Suk Chun†, Seo-Jung Han†, Dae-Seop Shin, Haushabhau S Pagire, Suvarna H Pagire, Gwi Bin Lee, Chong Hak Chae, Boryeong Pak, Suk-Won Jin, Young-Tae Chang, Seung Bum Park, Jin Hee Ahn, Myung Ae Bae, Dyes and Pigments, 2019, 171, 107720. (†Contributed equally)
  • 13. “Atroposelective Synthesis of PINAP via DynamicKinetic Asymmetric Transformation,” Seo-Jung Han, Vikram Bhat, Brian M. Stoltz, Scott C. Virgil, Adv. Synth. Catal. 2019, 361, 441–444.
  • 12. “Optimization of Benzimidazole Scaffold with a trans-Phenylcyclohexyl Acetic Acid as Diacylglycerol Acyltransferase-1 Inhibitors,” Yu Mi Pyun, Joon Hyun Oh, Hyun Jung Kwak, Ji Young Kim, Seo-Jung Han, Gwi Bin Lee, Suvarna H. Pagire, Haushabhau S. Pagire, Ki Young Kim, Won Hoon Jung, Sang Dal Rhee, Duck Hyung Lee, Jin Hee Ahn, Bull. Korean Chem. Soc. 2017,38, 570–573.
  • 11. “Nickel-CatalyzedIntramolecular C–O Bond Formation: Synthesis of Cyclic Enol Ethers,” Seo-Jung Han, Ryohei Doi, Brian M. Stoltz, Angew. Chem. Int. Ed. 2016, 55, 7437–7440.
  • 10. “A mild and efficient approach to enantioenriched α-hydoxyethyl α,β-unsaturated δ-lactams,” Seo-Jung Han, Brian M. Stoltz, Tetrahedron Lett. 2016, 57,2233–2235.
  • 9. “Discovery and optimization of adamantine carboxylic acid derivatives as potentdiacylglycerol  acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes,” Suvarna H. Pagire, Haushabhau S. Pagire, Gwi Bin Lee, Seo-Jung Han, Hyun Jung Kwak, Ji Young Kim, Ki Young Kim, Sang Dal Rhee, Jeong Im Ryu, Jin Sook Song, Myung Ae Bae, Mi-jin Park, Dooseop Kim, Duck Hyung Lee, Jin Hee Ahn, Eur. J. Med. Chem. 2015, 101, 716–735.
  • 8. “Synthesis and DiacylglycerolAcyltransferase-1 Inhibition of Azabicyclo[3.1.0]hexane Derivatives,” Seo-JungHan, Gwi Bin Lee, Hyun Jung Kwak, Suvarna H. Pagire, Ji Young Kim,Haushabhau S.  Pagire, Sung Bum Park, Chong Hak Chae, Joo Yun Lee, Ki Young Kim, Sang Dal Rhee, Hee Youn Kim, Sun Hye Shin, Myung Ae Bae, Mi-Jin Park, Dooseop Kim, Duck Hyung Lee, Jin Hee Ahn, Bull. Korean Chem. Soc. 2015, 36, 1586–1593.
  • 7. “Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules,” Yiyang Liu, Seo-Jung Han, Wen-Bo Liu, Brian M. Stoltz, Acc. Chem. Res. 2015, 48, 740–751.
  • 6. “Evolution of a Unified, Stereodivergent Approach to the Synthesis of Communesin F and Perophoramidine,” Seo-Jung Han, Florian Vogt, Jeremy May, Shyam Krishnan, MicheleGatti, Scott C. Virgil, Brian M. Stoltz, J. Org. Chem. 2015, 80, 528–547.
  • 5. “Stereochemical evaluation ofbis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters,” Chung Whan Lee, Seo-Jung Han, Scott C. Virgil, Brian M. Stoltz, Tetrahedron, 2014, 71, 3666–3670.
  • 4. “A New Method for the Cleavage of Nitrobenzyl Amides and Ethers,” Seo-Jung Han, Gabriel Fernando de Melo, Brian M. Stoltz, Tetrahedron Lett. 2014, 55, 6467–6469.
  • 3. “A Diastereodivergent Synthetic Strategy for the Syntheses of Communesin F and Perophoramidine,” Seo-Jung Han, Florian Vogt, Shyam Krishnan, Jeremy A. May, Michele Gatti, Scott C. Virgil, Brian M. Stoltz, Org. Lett. 2014, 16, 3316–3319.
  • 2. “Convergent and Enantioselective Total Synthesis of (–)-Amphidinolide O and(–)-Amphidinolide P,” Min-ho Hwang, Seo-Jung Han, Duck-Hyung Lee, Org. Lett. 2013, 15, 3318–3321.
  • 1. “A Stereoselective synthesis ofC26–C36 Fragment of Arenicolide A,” Jung lyul Lee, Seo-Jung Han, Duck-Hyung Lee, Bull. Korean Chem. Soc. 2009, 30, 1443–1444.

 

– 특허출원 및 등록

  • 8. “Novel pyrimido[4,5-d]pyrimidin-2-onederivatives as protein kinase inhibitors,” Seo-Jung Han, Tae Bo Sim, Do Hee Oh, Jae Eun Cheong, Dong Keon Hwang, KR10-2021-0033887
  • 7. “Novel naphthyridinone derivatives as a Ectonucleotidepyrophosphatase-phosphodiesterase inhibitors and use thereof,” Seo-Jung Han, Chan Sun Park, Sung Jun Kim, Jae Eun Cheong, KR 10-2020-0185961.
  • 6. “Novel phtalazine derivatives as a Ectonucleotidepyrophosphatase-phosphodiesterase inhibitors and use thereof,” Seo-Jung Han, Junwon Choi, Sanghee Lee, Chan Sun Park, SungJun Kim, Jae Eun Cheong, Hee Jin Jeong, Do Hee Oh, KR10-2020-0055335.
  • 5. “Novel pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors,” Seo-Jung Han, Tae Bo Sim, Do Hee Oh, Jae Eun Cheong, Dong Keon Hwang, PCT/KR2020/011455.
  • 4. “Novel pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors,” Seo-Jung Han, Tae Bo Sim, Do Hee Oh, Jae Eun Cheong, Dong Keon Hwang, CN202010851403.2.
  • 3. “Novel pyrimido[4,5-d]pyrimidin-2-onederivatives as protein kinase inhibitors,” Seo-Jung Han, Tae Bo Sim, Do Hee Oh, Jae Eun Cheong, Dong Keon Hwang, US 17/002,748.
  • 2. “Novel pyrimido[4,5-d]pyrimidin-2-one derivatives asprotein kinase inhibitors,” Seo-Jung Han, Tae Bo Sim, Do Hee Oh, Jae Eun Cheong, Dong Keon Hwang, KR 10-2019-0107018.
  • 1. “Fluorescent Probes for Imaging Blood Vessel and Their Uses,” Jin Hee Ahn, Seo-Jung Han, Myung Ae Bae, KR10-1555356 B1.