Caring for a better life
The protein kinase family of the human genome (kinome) is critically involved in diverse regulation of cellular signal transductions. Aberrant activation and dysregulation of certain protein kinases caused by mutation and over-expression have been implicated in a broad spectrum of human diseases such as cancer and inflammation. The identification of novel small molecules that can modulate dysregulated certain kinases becomes crucial in the field of drug discovery for targeted therapies. Our mission is to discover novel small molecule drug candidates for important diseases including cancers. Using small molecules that modulate kinase functions, Chemical Kinomics Research Center works on deciphering complicated phosphorylation-based cellular signaling networks and identification of novel molecular targets and discovery of new functions of known kinases.
Eun Joo Roh
- 2019 Discovery of VEGFR inhibitors – J. Med. Chem. Featured article
- 2019 Discovery of PDHK inhibitors – J. Med. Chem.
- 2019 Orthogonal GalNAc-Transferase – J. Am. Chem. Soc.
- 2018 Discovery of ACK1/GCK dual inhibitors – J. Med. Chem.
- 2018 Development of esophageal stent – ACS Nano.
- 2017 Discovery of ALK inhibitors – J. Med. Chem.
- 2020 Targeted therapy drug candidates for NRAS mutant driven
acute myeloid leukemia
- 2016 Targeted therapy drug candidates for sarcoma
- 2016 FLT kinase-targeted cancer therapy drug candidates
- 2014 Targeted therapy drug candidates for acute myeloid leukemia
Medicinal chemistry/Organic chemistry
Organic synthetic methods development
- Synthesis of drug-like compounds
- Pharmacophore-focused chemical libraries
Discovery of novel drug candidates
- In silico drug design
- Synthesis and optimization of derivatives
- Targeted therapy drug candidates
- Immunomodulatory drug candidates
- Drug candidates for infectious diseases
Chemical biology/Cancer biology/Immunology/Structural biology/Electrophysiology
CRISPR-Cas9 genome-wide screening
- Identification of novel therapeutic targets
- Assay development and screening in drug discovery
- X-ray structures of compound-target comoplexes
In vivo animal model development
- In vivo efficacy studies